glibenclamide相关论文
Administration of Fenugreek Seed Extract Produces Better Effects in Glibenclamide-Induced Inhibition
Objective:To evaluate the comparative effects of fenugreek (Trigonella foenum graecum) seed extract (FSE) alone and in c......
Glibenclamide(GBC)confers neuroprotection in animal models as well as retrospective clinical studies.This study determin......
Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein a
Aim: To evaluate the contribution of the impaired cytochrome P450 and breast cancer resistance protein (BCRP) activity a......
A new pharmacological effect of glibenclamide: induction of apoptosis in activated T cells by suppre
Aim: Glibenclamide, originally applied to treat type 2 diabetes mellitus, is currently known to exert a new pharmacologi......
A KCNJ11 in-frame 15bps deletion leading to glibenclamide-responsive neonatal diabetes mellitus in a
The ATP-sensitive K+ channel (KATP) controls insulin secretion from the islet.Mutations in KCN J11 can cause permanent a......
Glibenclamide attenuates myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic
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目的探讨基因分析对新生儿糖尿病的诊断意义和临床价值。方法选择本院内分泌遗传代谢科2012年2月至2013年9月收治并且进行家系基因......
Objective:To evaluate the antihyperglycemic activity of leaves ofHyptis suaveolens using streptozotocin model.Methods:Hy......
Protective effect ofLuffa acutangula extracts on gastric ulceration in NIDDM rats：Role of gastric mu
Objective:To study the comparative gastroprotective effect ofLuffa acutangula methanolic extract(LAM) and aqueous extrac......
In vitro α-amylase inhibitory activity and in vivo hypoglycemic effect of methanol extract of Citrus
Objective: To investigate the therapeutic effects of methanol extract of Citrus macroptera Montr. fruit in α-amylase in......
Hypoglycemic efficacy of Ocimum gratissimum and Vernonia amygdalina compared with insulin and gliben
本文通过对荣华二采区10...
目的 :观察二甲双胍对2型糖尿病模型大鼠尿nephrin(UNE)排泄的动态影响,探讨二甲双胍对糖尿病肾小球足细胞的保护作用。方法:将高......
目的:研究格列本脲对脑缺血再灌注损伤小鼠后期神经运动功能障碍的影响.方法:应用C57BL/6小鼠,制备局灶性脑缺血再灌注损伤模型,经......
Synthesis, Characterization, Biological and Docking Simulations of 4-(Benzylideneamino) Benzoic Acid
The present research paper presents the synthesis,characterization,biological and computational studies of 4-(benzyliden......
AIM: To study the effect of capsaicin on carotid sinus baroreceptor activity (CBA). METHODS: The functional curve of car......
,Alteration of binding sites for [3H]P1075 and [3H]glibenclamide in reno-vascular hypertensive rat a
Aim: The alterations of the binding sites for ATP-sensitive K+ channel (KATP)openers and blockers in aortic strips were ......
Aim:To study effects of hydrogen sulfide (H2S)on the carotid sinus baroreflex (CSB).Methods:The functional curve of the ......
,Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathio
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,Pharmacological evidence: a new therapeutic approach to the treatment of chronic heart failure thro
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,Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium cha
ATP.sensitive potassium channels (KATP) are energy sensors on the plasma membrane.By sensing the intracellular ADP/ATP r......
Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta-cells o
Objective:To investigate the antidiabetic,hypolipidaemic activities and histopathological changes ofIcacina trichantha(I......
目的:探讨姜黄素(Cur)与格列本脲(Gli)联用对2型糖尿病大鼠糖代谢的影响及其机制。方法:复制大鼠2型糖尿病模型,观察Cur(100 mg·k......
目的探讨降糖药格列苯脲与二甲双胍对2型糖尿病住院患者的有效性和安全性。方法将2型糖尿病患者180例随机分为格列苯脲组和二甲双......
Protective effect of the whole plant extract ofEvolvulus alsinoides on glycoprotein alterations in s
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Background It has been reported that hydrogen sulfide (H2S) could relax vascular smooth muscle by direct activation of K......
目的研究吗啡预处理对心肌的保护作用以及格列苯脲对其的影响。方法采用新生大鼠的原代心肌培养细胞作为研究对象,将培养心肌细胞......
比较了分别采用溶剂分散法和微粉化法制备的复方盐酸二甲双胍胶囊中格列本脲的含量均匀度及溶出均一性.结果表明,前法制备的胶囊中......
目的考察并比较自制复方二甲双胍片中格列本脲、二甲双胍与对照药格列本脲片、二甲双胍片的溶出度.方法以HPLC法测定含量,用转篮法......
目的观察格列美脲(glimepiride)治疗老年2型糖尿病(type 2 diabetes mellitus,T2DM)的疗效和安全性。方法60例T2DM老年患者随机分......
目的 探讨ATP敏感性钾通道（KATP）开放剂吡那地尔（Pin)对低氧低糖再复氧诱导的大鼠皮质神经细胞凋亡的影响。方法 用电镜和流式细胞分......
目的 探讨冠状动脉震颤发生的条件及和ATP敏感性钾通道的关系。方法 用优降糖诱发冠状动脉震颤后分别用尼可的尔、硝酸甘油观察两......
目的建立测定消渴平胶囊中格列苯脲含量的高效液相色谱法。方法色谱柱采用Kromasil C18柱（200mm×4.6mm,5μm）,流动相为磷酸二氢......
目的:研究国产格列美脲(Gli)对家兔、大鼠血糖及糖耐量水平和胰岛素释放的影响.方法:以正常Wister大鼠和家兔为实验对象,以给药前......
目的：观察格列美脲与格列本脲对2型糖尿病患者颈动脉粥样硬化的影响。方法：选择40例2型糖尿病患者,随机均分为格列美脲组和格列本脲......
目的：观察KATP通道开放剂预处理对在体缺血再灌注（ischemia／reperfusion，I／R）心脏的影响。方法：建立在体大鼠心脏缺血再灌注模型。将60只......
目的探讨用高效液相色谱（HPLC）法测定消糖灵胶囊中格列本脲的含量。方法采用HP ODS-Hypersil色谱柱（4.6 mm×200 mm,5μm）,柱温：20......
采用动态血糖监测技术比较新诊断2型糖尿病患者应用瑞格列奈（10例）和优降糖（10例）治疗4周后血糖谱的差异。结果显示,与优降糖组相比,瑞......
采用HPLC为对照分析法测定消渴丸中格列本脲的含量,应用偏最小二乘法(PLS)建立NIR光谱与格列本脲成分HPLC测定值之间的多元校正模......
目的:研究复方二甲双胍胶囊在健康受试者体内的药物动力学和相对生物利用度.方法:20名男性志愿者随机交叉口服复方二甲双胍胶囊(试......
目的: 在正常Wistar大鼠离体主动脉上,研究核苷酸类物质ATP,ADP,UDP,GTP及其代谢产物腺苷(Ade)对ATP敏感性钾通道(ATP-sensitive p......
为使Ⅱ型糖尿病及有关并发症的治疗达到简便、适用和良好的效果，该研究采用了精制蝮蛇抗栓酶加优降糖治疗Ⅱ型糖尿病，并与优降糖治疗......
目的探讨在实验性糖尿病大鼠体内联用18α-甘草酸二铵（DG）和格列本脲（Gli）时，DG对Gli药动学的影响。方法采用RP-HPLC测定实验性糖尿病大......
目的研究人体内细胞色素P450 2C9酶突变等位基因CYP2C9*3对格列本脲和氯诺昔康药代动力学的影响.方法采用PCR-RFLP方法对83名无血......
[目的]建立薄层扫描测定茯苓山药片中格列本脲含量。[方法]采用薄层扫描色谱法,氯仿-环己烷-乙醇-冰醋酸(8∶13∶1∶1)为展开剂,双......
本文用细胞内微电极技术观察了ＥＴ－１对家兔窦房结起搏细胞电生理活动的影响。所得结果如下：（１）在以ＥＴ－１作表面灌流时，起搏细胞的４相自动去极化的速......
在３０只隔高灌流颈动脉窦区的麻醉大鼠，观察了ＫＡＴＰ通道开放剂（ｃｒｏｍａｋａｌｉｍ，Ｃｒｏ）对颈动脉窦压力感受器反射的影响。结果如下：⑴以Ｃｒｏ（１０μｍｏｌ／Ｌ）隔离灌流大鼠左侧颈动脉窦区......
在30只隔离灌流颈动脉窦区的麻醉大鼠,观察了辣椒素(capsaicin,CAP)对颈动脉窦压力感受性反射的影响.结果显示(1)以CAP(1 μmol/L)......
建立了测定复方盐酸二甲双胍片中格列本脲含量及其均匀度的HPLC法.采用ODS(150 mm×4.6 mm,5μm)色谱柱,流动相为甲醇-pH3.5磷......
目的：探讨格列本脲对胶质母细胞瘤活性及细胞内酸碱变化的影响。方法：使用不同浓度的格列本脲（GHb)处理人胶质瘤细胞株U251和U87,通过......
